Win32, Can't format !

I have reason to believe my computer is infected with win32 virus. Ive tried a lot of things and cant get rid of it so I planned on formatting the hard drive but I cant even do that. When I try I get a message reading:
"Windows cannot format this drive. Quit any disk utilities or other programs that are using this drive, and make sure that no window is displaying the contents of the drive. Then try formatting again."
I close every program I can and get the same message and then try to go into task manager to close anything else but I cant open task manager in any way. How can I format my drive?!!
Thanks in advance
Paul

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